-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a -opioid pathway
نویسندگان
چکیده
Sandra Zoghbi, Aurélien Trompette, Jean Claustre, Mahmoud El Homsi, Javier Garzón, Gérard Jourdan, Jean-Yves Scoazec, and Pascale Plaisancié INSERM, U45, Lyon, IFR62, University Claude Bernard Lyon I, Faculté de Médecine R. Laennec, Lyon; INRA, Neuro-Gastroentérologie et Nutrition, Toulouse, France; and Department of Neuropharmacology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
منابع مشابه
β-Casomorphin-7 Regulates the Secretion and the Expression of Gastrointestinal Mucins through a μ-Opioid Pathway
We recently showed that β-casomorphin-7, a milk opioid peptide, strongly stimulates mucin secretion in rat jejunum through a nervous pathway and opioid receptor activation. In this study, the hypothesis that β-casomorphin-7 may also act directly on intestinal goblet cells was investigated in vitro in rat and human intestinal mucin-producing cells (DHE and HT29-MTX) using quantitative and semi-q...
متن کاملEffects of peptides derived from dietary proteins on mucus secretion in rat jejunum.
The hypothesis that dietary proteins or their hydrolysates may regulate intestinal mucin discharge was investigated in the isolated vascularly perfused rat jejunum using an enzyme-linked immunosorbent assay for rat intestinal mucins. On luminal administration, casein hydrolysate [0.05-5% (wt/vol)] stimulated mucin secretion in rat jejunum (maximal response at 417% of controls). Lactalbumin hydr...
متن کاملFood-derived peptides stimulate mucin secretion and gene expression in intestinal cells.
In this study, the hypothesis that food-derived opioid peptides besides β-casomorphin 7 might modulate the production of mucin via a direct action on epithelial goblet cells was investigated in HT29-MTX cells used as a model of human colonic epithelium. Seven milk whey or casein peptides, a human milk peptide, and a wheat gluten-derived peptide with proved or probable ability to bind μ- or δ-op...
متن کاملmiR-320 regulates inflammation in EAE through interference with TGF-β signaling pathway
Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...
متن کاملmiR-33-5p Regulates CREB to Induce Morphine State-dependent Memory in Rats: Interaction with µ Opioid Receptor
The aim of the present study was to examine the hypothesis that miR-33-5p attenuates morphine state-dependent (StD) memory via the µ opioid receptor by regulating cyclic AMP response element-binding protein (CREB). The effects of post-training morphine and morphine StD memory and their interaction with pre-test naloxone were evaluated using a single-trial inhibitory avoidance paradigm. Then, th...
متن کامل